Regeneration of autotransplanted avascular lymph nodes in the rat is improved by platelet-rich plasma.
Identifieur interne : 006059 ( Main/Exploration ); précédent : 006058; suivant : 006060Regeneration of autotransplanted avascular lymph nodes in the rat is improved by platelet-rich plasma.
Auteurs : Catarina Hadamitzky [Allemagne] ; Katrin S. Blum ; Reinhard PabstSource :
- Journal of vascular research [ 1423-0135 ] ; 2009.
Descripteurs français
- KwdFr :
- Animaux, Cellules dendritiques (anatomopathologie), Facteurs de l'âge, Femelle, Lymphangiogenèse (physiologie), Lymphocytes B (anatomopathologie), Lymphocytes T (anatomopathologie), Lymphoedème (), Modèles animaux de maladie humaine, Noeuds lymphatiques (), Noeuds lymphatiques (anatomopathologie), Noeuds lymphatiques (transplantation), Nécrose, Plasma riche en plaquettes, Rats, Rats de lignée LEW, Régénération (physiologie), Survie du greffon, Tissu sous-cutané (), Tissu sous-cutané (anatomopathologie), Transplantation autologue.
- MESH :
- anatomopathologie : Cellules dendritiques, Lymphocytes B, Lymphocytes T, Noeuds lymphatiques, Tissu sous-cutané.
- physiologie : Lymphangiogenèse, Régénération.
- Animaux, Facteurs de l'âge, Femelle, Lymphoedème, Modèles animaux de maladie humaine, Noeuds lymphatiques, Nécrose, Plasma riche en plaquettes, Rats, Rats de lignée LEW, Survie du greffon, Tissu sous-cutané, Transplantation autologue.
English descriptors
- KwdEn :
- Age Factors, Animals, B-Lymphocytes (pathology), Dendritic Cells (pathology), Disease Models, Animal, Female, Graft Survival, Lymph Nodes (blood supply), Lymph Nodes (pathology), Lymph Nodes (transplantation), Lymphangiogenesis (physiology), Lymphedema (prevention & control), Lymphedema (surgery), Necrosis, Platelet-Rich Plasma, Rats, Rats, Inbred Lew, Regeneration (physiology), Subcutaneous Tissue (blood supply), Subcutaneous Tissue (pathology), Subcutaneous Tissue (surgery), T-Lymphocytes (pathology), Transplantation, Autologous.
- MESH :
- blood supply : Lymph Nodes, Subcutaneous Tissue.
- pathology : B-Lymphocytes, Dendritic Cells, Lymph Nodes, Subcutaneous Tissue, T-Lymphocytes.
- physiology : Lymphangiogenesis, Regeneration.
- prevention & control : Lymphedema.
- surgery : Lymphedema, Subcutaneous Tissue.
- transplantation : Lymph Nodes.
- Age Factors, Animals, Disease Models, Animal, Female, Graft Survival, Necrosis, Platelet-Rich Plasma, Rats, Rats, Inbred Lew, Transplantation, Autologous.
Abstract
The aim of this study was to verify that subcutaneous lymph node transplantation inducing lymphatic regeneration is possible in healthy adult rats, in analogy to results obtained in other species. This rat model was used to determine the effects of lymph node fragmentation as well as sheep erythrocytes and platelet-rich plasma injection on the regeneration of the transplanted lymph nodes. The results show for the first time that the rat is an adequate model to study the regeneration of transplanted lymph nodes. Lymph node fragmentation seems to affect transplant regeneration negatively. An immune challenge by injection of sheep erythrocytes in the drainage area of the transplanted lymph nodes does not improve fragment regeneration. However, injection of syngeneic platelet-rich plasma containing several growth factors resulted in an improvement in regeneration. Lymph node fragment regeneration, although still experimental, could be relevant for lymphedema prevention. Acquired lymphedema has a high prevalence in developed countries as a consequence of the removal and/or radiotherapy of tumor-draining lymph nodes in cancer patients. This disease causes lifelong disability due to chronic swelling and increased risk of infections. It currently lacks an effective treatment.
DOI: 10.1159/000194269
PubMed: 19155630
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 003003
- to stream PubMed, to step Curation: 003003
- to stream PubMed, to step Checkpoint: 003003
- to stream Ncbi, to step Merge: 003171
- to stream Ncbi, to step Curation: 003171
- to stream Ncbi, to step Checkpoint: 003171
- to stream Main, to step Merge: 006131
- to stream Main, to step Curation: 006059
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Regeneration of autotransplanted avascular lymph nodes in the rat is improved by platelet-rich plasma.</title><author><name sortKey="Hadamitzky, Catarina" sort="Hadamitzky, Catarina" uniqKey="Hadamitzky C" first="Catarina" last="Hadamitzky">Catarina Hadamitzky</name><affiliation wicri:level="3"><nlm:affiliation>Institute for Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany. Hadamitzky.Catarina@MH-Hannover.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Functional and Applied Anatomy, Hannover Medical School, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Blum, Katrin S" sort="Blum, Katrin S" uniqKey="Blum K" first="Katrin S" last="Blum">Katrin S. Blum</name></author><author><name sortKey="Pabst, Reinhard" sort="Pabst, Reinhard" uniqKey="Pabst R" first="Reinhard" last="Pabst">Reinhard Pabst</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="RBID">pubmed:19155630</idno><idno type="pmid">19155630</idno><idno type="doi">10.1159/000194269</idno><idno type="wicri:Area/PubMed/Corpus">003003</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003003</idno><idno type="wicri:Area/PubMed/Curation">003003</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003003</idno><idno type="wicri:Area/PubMed/Checkpoint">003003</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003003</idno><idno type="wicri:Area/Ncbi/Merge">003171</idno><idno type="wicri:Area/Ncbi/Curation">003171</idno><idno type="wicri:Area/Ncbi/Checkpoint">003171</idno><idno type="wicri:Area/Main/Merge">006131</idno><idno type="wicri:Area/Main/Curation">006059</idno><idno type="wicri:Area/Main/Exploration">006059</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Regeneration of autotransplanted avascular lymph nodes in the rat is improved by platelet-rich plasma.</title><author><name sortKey="Hadamitzky, Catarina" sort="Hadamitzky, Catarina" uniqKey="Hadamitzky C" first="Catarina" last="Hadamitzky">Catarina Hadamitzky</name><affiliation wicri:level="3"><nlm:affiliation>Institute for Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany. Hadamitzky.Catarina@MH-Hannover.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Functional and Applied Anatomy, Hannover Medical School, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Blum, Katrin S" sort="Blum, Katrin S" uniqKey="Blum K" first="Katrin S" last="Blum">Katrin S. Blum</name></author><author><name sortKey="Pabst, Reinhard" sort="Pabst, Reinhard" uniqKey="Pabst R" first="Reinhard" last="Pabst">Reinhard Pabst</name></author></analytic><series><title level="j">Journal of vascular research</title><idno type="eISSN">1423-0135</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors</term><term>Animals</term><term>B-Lymphocytes (pathology)</term><term>Dendritic Cells (pathology)</term><term>Disease Models, Animal</term><term>Female</term><term>Graft Survival</term><term>Lymph Nodes (blood supply)</term><term>Lymph Nodes (pathology)</term><term>Lymph Nodes (transplantation)</term><term>Lymphangiogenesis (physiology)</term><term>Lymphedema (prevention & control)</term><term>Lymphedema (surgery)</term><term>Necrosis</term><term>Platelet-Rich Plasma</term><term>Rats</term><term>Rats, Inbred Lew</term><term>Regeneration (physiology)</term><term>Subcutaneous Tissue (blood supply)</term><term>Subcutaneous Tissue (pathology)</term><term>Subcutaneous Tissue (surgery)</term><term>T-Lymphocytes (pathology)</term><term>Transplantation, Autologous</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cellules dendritiques (anatomopathologie)</term><term>Facteurs de l'âge</term><term>Femelle</term><term>Lymphangiogenèse (physiologie)</term><term>Lymphocytes B (anatomopathologie)</term><term>Lymphocytes T (anatomopathologie)</term><term>Lymphoedème ()</term><term>Modèles animaux de maladie humaine</term><term>Noeuds lymphatiques ()</term><term>Noeuds lymphatiques (anatomopathologie)</term><term>Noeuds lymphatiques (transplantation)</term><term>Nécrose</term><term>Plasma riche en plaquettes</term><term>Rats</term><term>Rats de lignée LEW</term><term>Régénération (physiologie)</term><term>Survie du greffon</term><term>Tissu sous-cutané ()</term><term>Tissu sous-cutané (anatomopathologie)</term><term>Transplantation autologue</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Cellules dendritiques</term><term>Lymphocytes B</term><term>Lymphocytes T</term><term>Noeuds lymphatiques</term><term>Tissu sous-cutané</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Lymph Nodes</term><term>Subcutaneous Tissue</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>B-Lymphocytes</term><term>Dendritic Cells</term><term>Lymph Nodes</term><term>Subcutaneous Tissue</term><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Lymphangiogenèse</term><term>Régénération</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Lymphangiogenesis</term><term>Regeneration</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Lymphedema</term><term>Subcutaneous Tissue</term></keywords><keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>Lymph Nodes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age Factors</term><term>Animals</term><term>Disease Models, Animal</term><term>Female</term><term>Graft Survival</term><term>Necrosis</term><term>Platelet-Rich Plasma</term><term>Rats</term><term>Rats, Inbred Lew</term><term>Transplantation, Autologous</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Facteurs de l'âge</term><term>Femelle</term><term>Lymphoedème</term><term>Modèles animaux de maladie humaine</term><term>Noeuds lymphatiques</term><term>Nécrose</term><term>Plasma riche en plaquettes</term><term>Rats</term><term>Rats de lignée LEW</term><term>Survie du greffon</term><term>Tissu sous-cutané</term><term>Transplantation autologue</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim of this study was to verify that subcutaneous lymph node transplantation inducing lymphatic regeneration is possible in healthy adult rats, in analogy to results obtained in other species. This rat model was used to determine the effects of lymph node fragmentation as well as sheep erythrocytes and platelet-rich plasma injection on the regeneration of the transplanted lymph nodes. The results show for the first time that the rat is an adequate model to study the regeneration of transplanted lymph nodes. Lymph node fragmentation seems to affect transplant regeneration negatively. An immune challenge by injection of sheep erythrocytes in the drainage area of the transplanted lymph nodes does not improve fragment regeneration. However, injection of syngeneic platelet-rich plasma containing several growth factors resulted in an improvement in regeneration. Lymph node fragment regeneration, although still experimental, could be relevant for lymphedema prevention. Acquired lymphedema has a high prevalence in developed countries as a consequence of the removal and/or radiotherapy of tumor-draining lymph nodes in cancer patients. This disease causes lifelong disability due to chronic swelling and increased risk of infections. It currently lacks an effective treatment.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Basse-Saxe</li></region><settlement><li>Hanovre</li></settlement></list><tree><noCountry><name sortKey="Blum, Katrin S" sort="Blum, Katrin S" uniqKey="Blum K" first="Katrin S" last="Blum">Katrin S. Blum</name><name sortKey="Pabst, Reinhard" sort="Pabst, Reinhard" uniqKey="Pabst R" first="Reinhard" last="Pabst">Reinhard Pabst</name></noCountry><country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Hadamitzky, Catarina" sort="Hadamitzky, Catarina" uniqKey="Hadamitzky C" first="Catarina" last="Hadamitzky">Catarina Hadamitzky</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 006059 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 006059 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:19155630
|texte= Regeneration of autotransplanted avascular lymph nodes in the rat is improved by platelet-rich plasma.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:19155630" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |